Effects of endocrine disrupting chemicals on myelin development and diseases

In the central and peripheral nervous systems, myelin is essential for efficient conduction of action potentials. During development, oligodendrocytes Schwann cells differentiate ensure axon myelination, disruption these processes can contribute to neurodevelopmental disorders. adults, demyelination lead important disabilities, recovery capacities by remyelination often decrease with disease progression. Among environmental chemical pollutants, endocrine disrupting chemicals (EDCs) are major concern human health notably suspected participate in neurodegenerative diseases. this review, we have combined current knowledge on EDCs impacts including several persistent organic bisphenol A, triclosan, heavy metals, pesticides, nicotine. Besides, presented other modulators, pharmaceuticals phytoestrogen genistein, some which candidates treating demyelinating conditions but could also be deleterious as contaminants. The direct myelinating were considered well their indirect consequences myelin, particularly immune mechanisms associated conditions. More studies needed describe effects compounds further understand underlying relation potential disruption.